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KMID : 0369820100400050285
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Jorunal of Korean Pharmaceutical Sciences
2010 Volume.40 No. 5 p.285 ~ p.289
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Zero-order Delivery of Alfuzosin Hydrochloride with Hydrophilic Polymers
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Park Jun-Bom
Hwang Chang-Hwan
Noh Hyung-Gon
Chae Yu-Byeong
Song Jun-Woo
Kang Chin-Yang
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Abstract
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Manufacturing a multi-layered tablet such as Xatral XL(R) is more complex and expensive than monolayered tablets, but mono-layered tablets may have less favorable release properties depending on the pharmacodynamics and pharmacokinetics of the active ingredient. We therefore sought to develop a monolayer tablet with a similar dissolution profile to the commercial alfuzosin sustained-release triple layered tablet (Xatral XL(R)). We prepared four different mono-layered alfuzosin tablets with different concentrations of hydroxypropyl methycellulose and PVP K-90. Fomulation III with alfuzosion/mg-stearate/ HPMC/ PVP K-90 (10/5/110/95 mg/tab) has a similar dissolution rate to Xatral XL(R), with a similarity factor score of 81.4. However, the swelling and erosion rates of the two formulations were different, and NIR analysis showed differences in the mechanisms of drug release. Thus, although formulation III and Xatral XL(R) show similar dissolution rates, the mechanisms of drug release are different.
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KEYWORD
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Alfuzosin HCl, Xatral XL(R), HPMC, PVP, Mono-layered tablet
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